You could use pkg_resources functions to access files:
# __main__.py
import pkg_resources
from PIL import Image
print(pkg_resources.resource_string(__name__, 'README.txt'))
im = Image.open(pkg_resources.resource_stream('app', 'im.png'))
im.rotate(45).show()
Where zipfile contains:
.
|-- app
| |-- im.png
| `-- __init__.py
|-- README.txt
`-- __main__.py
To make zipfile executable, run:
$ echo '#!/usr/bin/env python' | cat - zipfile > program-name
$ chmod +x program-name
To test it:
$ cp program-name /another-dir/
$ cd /another-dir && ./program-name